I should start by say I am no position to give official advice, as while I studied this stuff a great deal prior to participating, I'm still learning the ropes and testing the overall market. I should also note, crypto has shifted so much in just a half decade that nobody can predict which coins or companies will prevail. Friendster, Myspace, and Facebook equivalents are not set yet. Bitcoin seems incredibly predictable and strong right now... but government involvement, industry shifts, scaling issues, or general in-fighting could change its (or any other coin/company's) course quickly.
Based on what I seen, they reputable ones seem like a fine option if you're already moving into the crypto space. Right now they are a great way to hedge your holdings with a stablecoin like USDC or USDT. I think it's important to remember that holding these high APYs is ultimately hedging your crypto "bets". If your bitcoin shoots up, your USDC or Tether is comparatively less valuable. If the opposite occurs the opposite is true. That's why the APY is so high on stablecoins. I would argue that the reason you get those returns is they are betting against the dollar. But as long as the dollar still holds value to you, and you're either opposed to banks or centralized finance industries... you could do much worse.
I tend to follow guys like Crypto_Birb and Scott Melker (whom I recommend), depending on the focus. You have ~50-70% in the cornerstones (BTC, ETH) for longterm (assuming market is healthy and the flux is predictably cycling), and you position yourself for down to 50% when you want to make move on alts. You have 15% in USDC or equivalent within a yield, and you put 15% into your alts or more risky maneuvers. When pick a leveling in/out strategy and you STICK WITH IT, and use the profits for either savings or physical assets like Gold, Silver, Land etc...
Finally, I am more of a pessimist on all things. This current bubble is just that. There is some differences between this an 2013 and 2017 from all indications I can see. Percentage-wise and sheer numbers indicate acceptance is higher than ever and more people are ideologically buying into the need for decentralized financial options. But that doesn't mean there won't be a bear market coming, and it will be like many... long and painful for those who aren't prepared. Be prepared. Don't overexpose yourself EVER. Level out and don't fall for FOMO. Keep a moonbag of everything in case it becomes the next bitcoin, but 80%+ of anything you own should be liquidated at varying gains (leveling out). Consider 2035, not next week, when considering purchases.