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Interesting, a Johns Hopkins page says that since fasting decreases movement in the gallbladder which causes cholesterol to overwhelm the bile.My wife starting intermittent fasting and is now having issues with gallstones. She never had that issue prior to IF.
Maybe she will acclimate over time if that's the case...
Edit: check out this study, looks like gallbladder cholesterol peaks around 15 hours (more than 10 hr or 20 hr), but it declines over extended multi day fasts. So depending on the fasting window she's already on, if your wife really wants to do IF perhaps she could consider trying a longing fasting period.
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