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I've seen the videos about Ovchartkas, Kangols, and other "wolf killers" fighting off wolves, or even outright killing them, including even in 1v1 scenarios. However, from what I've seen, the wolves are usually very small.I might take a 150+ lb Tosa Inu over a gray wolf. Not definitively, but wolves fight for survival/to protect food, etc. A massive dog that's bred to fight like a Tosa Inu isn't interested in survival, it will go to the death. The wolf would likely look for an escape route once it realized how formidable its opponent was. The wolf wants to survive, the Inu wants to kill.
Normally, I always lend a steep favor to mass, but it isn't always about mass. I know some domestic breeds have been bred specifically to be formidable, but I would be hesitant to take any domesticated canine against the largest gray wolves: the ones weighing up to 75kg-80kg. Because of head size. There are documentaries out there about this. The wolf's head is roughly double the size of domesticated canines. Smaller head size in canines is associated with their diminished aggressive traits. This is why the wolf has a bite force of roughly double to triple even the mighty Kangols, Tosas, and Mastiffs.
Furthermore, one thing observed from the history of barbaric dog pit fighting is that often a smaller dog will ultimately prevail not just because they get a bite on, and hold its grip fanatically, but because they have superior endurance. Just like in the UFC, dogfights often become contests of attrition. No domestic canine has the endurance of a wolf. The wolves in the arctic have been observed maintaining a sprint for over 5 miles straight eventually running down the Elk.
Coincidentally, I found myself marveling at the powerful front legs of the alpha wolf from Yellowstone in this video just a few weeks ago. And this isn't even a Timber Wolf (the ones that grow the largest).
Although, more importantly, I wasn't speaking specifically to the capacity of an invidual canine to be deadly. I was remarking on the fact that wolves are the most deadly because they are the least domestic. In that way, they are even more hostile, genetically, than the most aggressive domesticated breeds like Pit Bulls. Wolves, Dingos, African Wild Dogs...these are the deadliest canines if factoring in the frequency of human interaction with them. They prefer to avoid us. But if they're hungry, there isn't thousands of years of selective breeding working against them. We are not friends: only foe or food.