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Agreed. Plus, what if something happens in the future and Down Syndrome becomes an evolutionary advantage? Like maybe there’s another pandemic but only those with Down Syndrome are immune, or aliens invade and their weakness is Down Syndrome? You never know.
You might be onto something! If you subscribe to the "Many-Worlds" interpretation of the multiverse hypothesis, which proposes that every possible outcome of a quantum event plays out in its own separate universe, then your precise scenario is either unfolding right now or has already occurred.