His standup is ugly, but efficient. An unorthodox, awkward style is more efficient the more classical trained your opponent is in many circumstances leading to odd striking exchange winners. Jardine Chuck comes to mind.
Izzy's key here is to take out DDP's legs before he can use his physicality to take control of the fight. DDP will make it an ugly fight, quickly, so the first two rounds will be very telling. DNDDP (Double Nostril Dricus Du Plesis) has shown to have a 5 round gas tank. It's a really hard fight for Izzy everywhere.
I was picking DDP to win against Izzy before he even fought Whittaker because he seemd like too good of a matchup for him. Now with each of them having fought DeSean, I think the scales are tipped heavily in DDP's favor. Momentum, career youth, rock solid chin (Sodić KO'd him at WW), and 5 years Izzy's junior after Izzy has had a long layoff and coming off a loss. DDP by submission round 3.