Coronavirus not very megathread.

Nimrod is an absolute shit talker. Pay him no heed as he will melt your brain with his paranoid delusions and conspiracy theories. He has me on block as I called him out on his bullshit one too many times.

Come to think of it maybe you should stay and take him to school :D
I wish I would have known this before I engaged him. I feel dumber having even had the conversation...
 
I mean, according to you it's not real, right? So...

No I say you are in phantasy land .. and there is a high probability youre talking utter BS ..

Of course you can never prove it.. anyways have a great day ..
 
No I say you are in phantasy land .. and there is a high probability youre talking utter BS ..

Of course you can never prove it.. anyways have a great day ..
Uh, I'd be happy to prove it to you in a DM.
 
I wish I would have known this before I engaged him. I feel dumber having even had the conversation...

Ah talking to one of the retards on my ignore list. lol.. good luck man ..

a bird in the hand is worth two in the bush
 
Lol, I just had to boot out a lady at work who had a meeting with one of our facilities guys to sell us PPE. She wasn't vaccinated. Really nice woman but kind of funny that she wasn't vaccinated but selling Covid protection. I did say sorry a few times but hopefully when she sorts it out she can come back in.
Thats ridiculous.
 
I was vaccinated with both Moderna shots as soon as I was able. I got COVID-19 anyway and it nearly took my life. And I'm a healthy guy in my 30's. I can't imagine being older or having health complications and getting it. Now I see why so many people are dying. It's definitely not like getting the flu...

Question for you: How long was it between when you were vaccinated and when you came down with covid?

The reason I ask is because research has now shown that the antibodies from vaccination decline at something like 40% per month and become useless after 6 months on average. Also, there are some indications, though no solid evidence or proof yet, that the shots may result in vaccine enhanced infections (those who were vaccinated get hit worse) as the vaccines wear off and/or with certain variants of the virus.
 
Question for you: How long was it between when you were vaccinated and when you came down with covid?

The reason I ask is because research has now shown that the antibodies from vaccination decline at something like 40% per month and become useless after 6 months on average. Also, there are some indications, though no solid evidence or proof yet, that the shots may result in vaccine enhanced infections (those who were vaccinated get hit worse) as the vaccines wear off and/or with certain variants of the virus.
It was nearly three months to the day. I know because my doctor wanted to full timeline of everything.

That's really interesting, though. I wonder if that was the case... I do know that it was the Delta Variant.
 
I'm sure you're not, because that would destroy your delusion.

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Good Night..
 
It was nearly three months to the day. I know because my doctor wanted to full timeline of everything.

That's really interesting, though. I wonder if that was the case... I do know that it was the Delta Variant.

Looks like you have a good doc. 3 months should put you inside the effective time limit of the vaccines, but getting whacked with Delta might have something to do with it. The known versions of Delta shouldn't hit you with a vaccine enhanced infection, but these darn things mutate fast and staying on top of every last variation isn't easy. The problem is Delta is fairly close to the vaccine enhancement stage and it wouldn't take much to get there.

This paper was from about 3 weeks ago and goes over Delta and VEI.
https://www.biorxiv.org/content/10.1101/2021.08.22.457114v1.full
mRNA-based vaccines provide effective protection against most common SARS-CoV-2 variants. However, identifying likely breakthrough variants is critical for future vaccine development. Here, we found that the Delta variant completely escaped from anti-N-terminal domain (NTD) neutralizing antibodies, while increasing responsiveness to anti-NTD infectivity-enhancing antibodies. Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity. Unique mutations in the Delta NTD were involved in the enhanced infectivity by the BNT162b2-immune sera. Sera of mice immunized by Delta spike, but not wild-type spike, consistently neutralized the Delta 4+ variant without enhancing infectivity. Given the fact that a Delta variant with three similar RBD mutations has already emerged according to the GISAID database, it is necessary to develop vaccines that protect against such complete breakthrough variants.
 
Looks like you have a good doc. 3 months should put you inside the effective time limit of the vaccines, but getting whacked with Delta might have something to do with it. The known versions of Delta shouldn't hit you with a vaccine enhanced infection, but these darn things mutate fast and staying on top of every last variation isn't easy. The problem is Delta is fairly close to the vaccine enhancement stage and it wouldn't take much to get there.

This paper was from about 3 weeks ago and goes over Delta and VEI.
https://www.biorxiv.org/content/10.1101/2021.08.22.457114v1.full
mRNA-based vaccines provide effective protection against most common SARS-CoV-2 variants. However, identifying likely breakthrough variants is critical for future vaccine development. Here, we found that the Delta variant completely escaped from anti-N-terminal domain (NTD) neutralizing antibodies, while increasing responsiveness to anti-NTD infectivity-enhancing antibodies. Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity. Unique mutations in the Delta NTD were involved in the enhanced infectivity by the BNT162b2-immune sera. Sera of mice immunized by Delta spike, but not wild-type spike, consistently neutralized the Delta 4+ variant without enhancing infectivity. Given the fact that a Delta variant with three similar RBD mutations has already emerged according to the GISAID database, it is necessary to develop vaccines that protect against such complete breakthrough variants.
I'm going to read up on this... Because I've been wondering how this could have happened. I was vaccinated, I barely left my house, and wore a mask when I did. I have a child who has health concerns because he has Down Syndrome, so I was extra careful. But I got it anyways. It would be troubling to me if the vaccine not only didn't protect me, but caused the symptoms to be even worse.
 
I'm going to read up on this... Because I've been wondering how this could have happened. I was vaccinated, I barely left my house, and wore a mask when I did. I have a child who has health concerns because he has Down Syndrome, so I was extra careful. But I got it anyways. It would be troubling to me if the vaccine not only didn't protect me, but caused the symptoms to be even worse.

That's a hell of a tough situation you're in, you have my sympathies. The really troubling part is we knew this might happen since it was disclosed in the FDA filings, yet we didn't do the research to definitively exclude the possibility as we've done with nearly every other vaccine.

Excerpt from FDA filings
https://www.fda.gov/media/144416/download
Available data do not indicate a risk of vaccine-enhanced disease, and conversely suggest
effectiveness against severe disease within the available follow-up period. However, risk of
vaccine-enhanced disease over time, potentially associated with waning immunity,
remains
unknown
and needs to be evaluated further in ongoing clinical trials and in observational studies
that could be conducted following authorization and/or licensure.

And then this came out about a month ago
https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).

The good news is any virus enhancing effects from the vaccine should wear off in time since there's no long term memory B cell activation, so once the active antibodies go to zero you'll be back at the baseline. Which unfortunately still leaves your daughter at risk.
 
I was vaccinated with both Moderna shots as soon as I was able. I got COVID-19 anyway and it nearly took my life. And I'm a healthy guy in my 30's. I can't imagine being older or having health complications and getting it. Now I see why so many people are dying. It's definitely not like getting the flu...
We're overlooking something Basic I think. Genetic disposition, blood type (I realize there's been some research into this) or mineral deficiencies. Something. Or it could be as simple as the more concentrated the dose the more severe the symptoms. Lots of older people shrug it off while it hits some robust apparently healthy people like a truck. Sneaky fucker of a thing.
 
Remember, you shed less virus and a much more shorter period of time with the vaccine, if you even get infected (which the vaccine reduces the chances of)

A 4-year-old Texas girl has died of COVID-19 — which she likely contracted from her mom, a staunch anti-vaxxer, the grieving parent said.
Harwood said she had tested positive the previous day, with her and her fiancé, William Tucker, already out of work because they were sick and quarantining at home.

“I was one of the people that was anti, I was against it,” she told her local paper of the shots.
“Now, I wish I never was,” she admitted.

 
Remember, you shed less virus and a much more shorter period of time with the vaccine, if you even get infected (which the vaccine reduces the chances of)





Her daughter still would have got it if she was vaxxed.

God, you are a vile fucking person.
 
We're overlooking something Basic I think. Genetic disposition, blood type (I realize there's been some research into this) or mineral deficiencies. Something. Or it could be as simple as the more concentrated the dose the more severe the symptoms. Lots of older people shrug it off while it hits some robust apparently healthy people like a truck. Sneaky fucker of a thing.

It's possible. Certain races are more vulnerable and there's also studies out which show a correlation between zinc & vitamin D deficiencies and a higher likelihood of severe covid outcomes. Could be one or more of those things, could be vaccine effects, could be something else we haven't discovered yet. Or maybe he drew the short straw. Problem is figuring out what happened in an individual case is really hard to do when we're still in the early stages of doing the research to find & characterize all the various factors, and it's even harder when everything relating to covid is highly politicized & toxic as hell.
 
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