Pretty much the same for me at the beginning and end. My current job was given to me by a friend after he suffered an unfortunate accident and ended up disabled. He knew that even though I didn't have the formal educational requirements for it I had all the skills needed and then some and could do the job no problem, so he offered to put me in before he tendered his resignation. All I had to do was not be a drooling dingus during the interview and I was in.
My first couple jobs out of university were short term contracts at companies where I'd done work terms when I was still in school. First longer term job was at a company where one of my professors worked when he wasn't teaching, he put in some good words for me and got me hooked up with the right folks to get me in.
In between there was a ton of networking both within industry groups and also from folks I know from various social activities outside work.