According to independent study, FDA approval doesn't mean too much.
For example, the MMR, which has been on the market for decades at the time of this study by Cochrane, was found to have "inadequate safety data" both pre and post marketing (meaning the clinical trials and "real world studies"). Lo and behold, it was decades AFTER licensure they realized MMR causes increase rate of seizure and chronic epilepsy.... whoopsie!
FDA is funded almost 50% by the pharmaceutical industry, and conflicts of interest abound. They have been caught sleeping at the wheel on numerous occasions, and they ARE NOT independent. People who pay attention realize that the FDA is not some omniscient benevolent organization, and they are rightfully cautious.